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Important experimental evidence showing that regulation protects infected animals against 'over-zealous' immune responses of either type 1 or type 2

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In this work, we use proteomics screening to identify substrates ubiquitylated by TRIP12, the HECT-type E3 ubiquitin ligase that specifically assembles K29-linked ubiquitin chains and adds K29 branched linkages off the K48-linked chains 10 , and identify the OTU-family DUB, OTUD5

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